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ÀÛ¼ºÀÏ : 16-01-22 17:38
20160130_Soyoung
 ±Û¾´ÀÌ : DSN
Á¶È¸ : 1,044  
1. A Zinc Finger Motif-Containing Protein Is Essential for Chloroplast RNA Editing (2015) _ Plos Gene.
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005028
RanBP2 type Zinc finger protein°ú °ü·ÃÇÑ ³í¹®À» ã¾Æº¸´Ù ¾Ë°Ô µÈ ³í¹®ÀÔ´Ï´Ù. ¾Ö±âÀå´ëÀÇ RanBP2 type Zinc finger proteinÀÇ ÇϳªÀÎ OZ1ÀÌ chloroplast editing factorÀÎ ORRM1°ú binding ÇÏ´Â °ÍÀ» Y2H·Î º¸¿©ÁÖ°í °¢°¢ÀÇ mutant¿Í wild typeÀ» ºñ±³ÇÔÀ¸·Î½á À̵é proteinÀÌ chloroplast RNAÀÇ C adenylation¿¡ °ü¿©ÇÑ´Ù´Â °ÍÀ» º¸¿©ÁÖ°í ÀÖ½À´Ï´Ù.

2. ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure (2016) _ Cell  <<¼±Á¤>>
http://www.cell.com/cell/abstract/S0092-8674(15)01702-X
´õÀÌ»ó transcription µÇÁö ¾Ê´Â mRNA°¡ ¹¶Ãļ­ Çü¼ºµÇ´Â stress granuleÀÇ °æ¿ì »ç¶÷¿¡¼­ ½Å°æ°è ÀÌ»óÀ» ÀÏÀ¸Å²´Ù°í ÇÕ´Ï´Ù. ÀÌ ³í¹®¿¡¼­´Â yeast systemÀ» ÀÌ¿ëÇÏ¿© stress granule Çü¼º °úÁ¤¿¡¼­ protein-protein interaction°ú ÇÔ²² ATP°¡ ¾î¶² ¿ªÇÒÀ» ÇÏ´ÂÁö¸¦ stainingÀ» ÅëÇÑ imaging°ú proteom ºÐ¼® µîÀ» ÅëÇØ º¸¿©ÁÖ°í ÀÖ½À´Ï´Ù.

3. Single-Cell Telomere-Length Quantification Couples Telomere Length to Meristem Activity and Stem Cell Development in Arabidopsis (2015) _ Cell Reports
http://www.sciencedirect.com/science/article/pii/S2211124715003885
È£¿µ¿Àºü°¡ Áö³­ Àú³Î È帷Π¿Ã·È´ø ³í¹®ÀÔ´Ï´Ù. ¾Ö±âÀå´ë¿¡¼­ telomereÀÇ ±æÀÌ¿Í ¿ªÇÒ°£ÀÇ °ü°è¿¡ ´ëÇؼ­ ¿©Å±îÁö Å©°Ô ¾Ë·ÁÁöÁö ¾Ê¾Ò½À´Ï´Ù. ÇÏÁö¸¸ ÀÌ ³í¹®¿¡¼­ telomereÀÇ ±æÀÌ°¡ ª¾ÆÁø µ¹¿¬º¯À̸¦ Cy3 stainingÀ» ÅëÇØ Ã£¾Æ³»°í, µ¹¿¬º¯ÀÌÀÇ »Ñ¸®¿¡¼­ meristemic region°ú root length°¡ ª¾ÆÁ³À½À» ÅëÇØ telomereÀÇ ±æÀÌ¿Í cell division-differentiation°£ÀÇ °ü°è¸¦ º¸¿© ÁÖ¾ú½À´Ï´Ù. ÀÌ ´ÙÀ½¿¡ À̸¦ ÀÌ¿ëÇÏ¿© ¾î¶² ¿¬±¸¸¦ ÇÒÁö¿¡ ´ëÇÑ ºÎºÐÀ» Á» ´õ »ý°¢ÇÒ ÇÊ¿ä°¡ ÀÖÀ» °Í °°½À´Ï´Ù.

4. Contribution of NAC Transcription Factors to Plant Adaptation to Land (2014) _ Science
http://science.sciencemag.org/content/343/6178/1505.full
Çö¿ì¿Àºü²² Ãßõ¹ÞÀº ³í¹®ÀÔ´Ï´Ù. ¾Ö±âÀå´ë¿¡¼­ xylem differentiation¿¡ °ü¿©ÇÑ´Ù°í ÀÌ¹Ì ¾Ë·ÁÁø transcription factorÀÎ NACÀÇ homologue¸¦ °¡Àå ´Ü¼øÇÑ ÇüÅÂÀÇ À°»ó½Ä¹°ÀÎ À̳¢¿¡¼­ ã¾Æ À̵éÀÇ lof¿Í ox¿¡¼­ xylem ¹ß´Þ ¹× ¹°ÀÇ À̵¿À» È®ÀÎÇÏ¿´½À´Ï´Ù. À̸¦ ÅëÇØ ÁøÈ­Àû Ãø¸é¿¡¼­ NAC transcription factorÀÇ ¿ªÇÒÀ» º¸¾Ò½À´Ï´Ù.

5. A predictive computational framework for direct reprogramming between human cell types (2016) _ Nature genetics
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3487.html
¸¶Âù°¡Áö·Î Çö¿ì¿Àºü²² Ãßõ¹ÞÀº ³í¹®ÀÔ´Ï´Ù. Computational analysis¸¦ ÅëÇØ human cell¿¡¼­ transdifferentiation¿¡ °ü¿©ÇÏ´Â transcription factor¸¦ ºÐ¼®ÇÏ°í À̸¦ ÅëÇØ »õ·Î¿î transdifferentiationÀ» ¿¹ÃøÇß´Ù°í ÇÏ´Â ³í¹®ÀÔ´Ï´Ù. ¿Àºü²²¼­ ÃßõÇØ ÁÖ½Ç ¶§, ¹ßÇ¥ ÇÏ°Ô µÉ °æ¿ì¿¡ ÇÁ·Î±×·¥ÀÇ ¾Ë°í¸®Áò ÀÚüº¸´Ù´Â µ¿¹°¿¡¼­´Â ¾î´ÀÁ¤µµ±îÁö ÁøÇàÀÌ µÇ¾î ÀÖ´ÂÁö¿¡ ÁßÁ¡À» µÎ°í Å©°Ô ¾î·Á¿ö ÇÒ ÇÊ¿ä ¾ø´Ù°í ÇϼÌÁö¸¸ Á¦ »ý°¢¿£ ¾Ë°í¸®Áò ÀÚüµµ ¾î´À Á¤µµ ÀÌÇØ ÇÒ ¼ö ÀÖµµ·Ï ÇØ¾ßµÉ °Í °°½À´Ï´Ù.

´Ê¾î¼­ Á˼ÛÇÕ´Ï´Ù. º¸½Ã°í Á¦°¡ ¹ßÇ¥ÇßÀ¸¸é ÇÏ´Â ³í¹®À» Åä¿äÀÏ ÀÚÁ¤±îÁö ¿¬±¸½Ç Ä«Åå¹æ¿¡¼­ ÅõÇ¥ÇØÁֽøé ÁÁ°Ú½À´Ï´Ù.